Ephedra: A Dangerous Supplement - A review at Athlete. In. Me. com. Ephedra: A Dangerous Supplement. Author. Stan Reents, Pharm. DOriginal Posting. AM. Last Revision: 0. AMOn February 1. 7, 2. Baltimore Orioles pitcher Steve Bechler died of heat stroke while practicing in Florida. This ruling went into effect on April 1. In this article, I will summarize ephedra, and, some of the FDA actions regarding its regulation in the US. HISTORY OF EPHEDRAEphedra, also called . Astrup A, et al. 1. Lenz TL, et al. 2. Nevertheless, some researchers argue that caffeine and ephedrine have been used together successfully as a weight loss aid in obese subjects without problems. Astrup A, et al. 1. Toubro S, et al. 1. Yet, an equally compelling argument can be made against the use of caffeine+ephedra: In 2. New England Journal of Medicine describing a 1. MI minutes after ingesting 2. Traub SJ, et al. 2. Another report, appearing also in 2. Vahedi K, et al. 2. Unfortunately, this information was either not passed on to Baltimore Orioles pitcher Steve Bechler or he chose to ignore it. FDA ACTIONS REGARDING EPHEDRA SUPPLEMENTSPrior to the death of Steve Bechler in 2. FDA had been trying to ban the sale of this substance for years. In 2. 00. 0, Haller and Benowitz reviewed 1. FDA between June 1, 1. March 3. 1, 1. 99. In an attempt to compare the rates of adverse reactions from ephedra supplements against other types of herbal supplements, investigators at UCSF analyzed adverse reactions to herbal products reported to the American Association of Poison Control Centers during 2. In the most thorough analysis to date, the RAND Corporation, at the request of the US Department of Health and Human Services, performed a comprehensive search and review of published reports on ephedra. GMPAnother problem that DSHEA created when it was passed in 1. Even more worrisome is a lack of consistency between 2 lots of the same brand: When the University of Arkansas researchers compared different lots of the same brand, variations in ephedrine content ranged as high as 2. Gurley BJ, et al. This is the side of the story that consumers need to be aware of. Ephedra can also interfere with heat loss, as in the case of Steve Bechler. Clemons JM, et al. De. Meersman R, et al. ![]() Ephedra nevadensis is NOT Ephedrine. Ephedra: Therapeutic use, Treatment. Diet Pills: Composition. Therapeutic use, Treatment. FDA on ephedra: Laws: Diet. The act prohibits the sale of dietary supplements containing ephedrine group alkaloids. Popular Ergogenic Drugs and Supplements in Young Athletes. Erowid is seeking professional mobile UX developers. Yellow swarm with ephedra - Buy High Potency. Sidney KH, et al. SUMMARY: WHY THE SALE OF HERBAL EPHEDRA SHOULD BE PROHIBITED. FOR MORE INFORMATIONConsumers Union, publisher of the magazine Consumer Reports, provides a fact sheet on ephedra on their web site: www. ![]() Consumers. Union. The effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet. Int J Obes Relat Metab Disord 1. Thermogenic, metabolic, and cardiovascular responses to ephedrine and caffeine in man. Int J Obes Relat Metab Disord 1. S4. 1- S4. 3. Physical fitness, mortality and obesity. Int J Obes Rel Metab Disord 1. S4. 1- S4. 4. The relative safety of ephedra compared with other herbal products. Ann Intern Med 2. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Selected cardiac and metabolic responses to pseudoephedrine with exercise. J Clin Pharmacol 1. Adverse events associated with ephedrine- containing products: Texas, December 1. September 1. 99. 5. Factors influencing the reinforcing and subjective effects of ephedrine in humans. Psychopharmacol (Berl)1. Cardiopulmonary and subjective effects of a 6. J Sports Med Phys Fit. Sympathomimetics and exercise enhancement: all in the mind? Pharmacol Biochem Behav 1. The need for regulation of dietary supplements - lessons from ephedra. JAMA 2. 00. 3; 2. Ephedrine abuse among 3. Am J Addict. 19. 98; 7: 2. Content versus label claims in ephedra- containing dietary supplements. Am J Health- Syst Pharm 2. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2. 00. Hemodynamic effects of ephedra- free weight- loss supplements in humans. Am J Med 2. 00. 5; 1. Concentrations of ephedra alkaloids and caffeine in commercial dietary supplements. J Anal Toxicol 2. Phenylpropanolamine and the risk of hemorrhagic stroke. N Engl J Med 2. 00. Cardiac arrhythmia in a professional football player. Was ephedrine to blame? Phys Sportsmed 2. Cardiorespiratory fitness, body composition, and all- cause and cardiovascular disease mortality in men. Am J Clin Nutr 1. Supplemental products used for weight loss. J Am Pharm Assoc 2. Arterial blood pressure response to heavy resistance exercise. J Appl Physiol. 19. Fed Reg 1. 98. 2; 4. Suspected caffeine and ephedrine toxicosis resulting from ingestion of an herbal supplement containing guarana and ma huang in dogs: 4. J Am Vet Med Assoc 2. Adverse events associated with ephedrine- containing products: Texas, December 1. September 1. 99. 5. JAMA 1. 99. 6; 2. Adverse cardiovascular events temporally associated with ma huang, an herbal source of ephedrine. Mayo Clinic Proc 2. Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta- analysis. JAMA 2. 00. 3; 2. Safety and efficacy of long- term treatment with ephedrine, caffeine and an ephedrine/caffeine mixture. Int J Obes Relat Metab Disord 1. S6. 9- S7. 2. Dietary supplements containing ephedra alkaloids. N Engl J Med 2. 00. Ischaemic stroke in a sportsman who consumed Ma Huang extract and creatine monohydrate for body building. J Neurol Neurosurg Psychiatry 2. Pharmacokinetics and cardiovascular effects of ma- huang (Ephedra sinica) in normotensive adults. J Clin Pharmacol. He is a member of the American College of Sports Medicine (ACSM) and holds current certifications from ACSM (Health & Fitness Specialist), ACE (Health Coach) and has been certified as a tennis coach by USTA. He is the author of Sport and Exercise Pharmacology (published by Human Kinetics) and has written for Runner's World magazine, Training and Conditioning, Club Solutions, and other fitness publications. Browse By Topic: banned substances, dietary supplements, energy drinks, food labels, performance- enhancing substances, sports nutrition. Will Ephedra Products Last?
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